ASSOCIATION OF LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-5 4037C>T VARIANT WITH NEPHROPATHY IN ADOLESCENTS WITH TYPE 1 DIABETES MELLITUS
نویسندگان
چکیده
Micro-vascular complications such as diabetic nephropathy (DN) develop in patients with uncontrolled T1DM. Low density lipoprotein receptor-related protein 5 (LRP5) is the co-receptor ligand of Wnt signaling pathway. Many single nucleotide variants have been identified human LRP5 gene and were reported to be associated metabolic disorders. The Wnt/β-catenin pathway has proposed play an important role a variety disorders including nephropathy. However, studies investigating variant T1DM are limited.
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ژورنال
عنوان ژورنال: Al-Azhar Journal of Pediatrics
سال: 2022
ISSN: ['1110-7774']
DOI: https://doi.org/10.21608/azjp.2022.274058